Essential Pharmaceutics by Ashlee D. Brunaugh & Hugh D. C. Smyth & Robert O. Williams III

Author:Ashlee D. Brunaugh & Hugh D. C. Smyth & Robert O. Williams III
Language: eng
Format: epub
ISBN: 9783030317454
Publisher: Springer International Publishing

(e) Thixotropic flow : In these systems, application of shear results in gradual decrease in viscosity followed by a recovery. This can be thought of as a reversible transition between an elastic solid state and a liquid state. These systems can flow like a liquid when exposed to high shear rates (such as the shaking of a bottle). When the shear stress is removed, the system reverts back to the elastic solid state over time due to rebuilding of internal network structures of the material. This type of system is useful because when the formulation is in the elastic solid state, the particles have reduced tendency to settle due to the viscosity of the vehicle.

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